protein transport protein Sec31A (SEC31-related protein A, SEC31-like 1, ABP125, ABP130, Web1-like protein, SEC31A, KIAA0905, SEC31L1, HSPC275, HSPC334)

Function

• component of COPII coat

Structure

• belongs to the WD repeat SEC31 family
• contains 7 WD repeats

Compartment

• cytoplasm, cytoplasmic vesicle
• COPII-coated vesicle membrane
• peripheral membrane, cytoplasmic side
• endoplasmic reticulum membrane
• association with membranes is GTP-dependent

Alternative splicing

named isoforms=8

Expression

• abundantly & ubiquitously expressed

Pathology

• chromosomal translocation t(2;4)(p23;q21) involving SEC31A with ALK is associated with inflammatory myofibroblastic tumors

More general terms

• WD repeat protein family
• phosphoprotein

Component of

• COPII coat

Database

• UniProt: http://www.uniprot.org/uniprot/O94979.html