ALK tyrosine kinase receptor; anaplastic lymphoma kinase; CD246 (ALK)

Function

• receptor for pleiotrophin
• tyrosine-protein kinase activity
• role in the normal development & function of the nervous system
• phosphorylates almost exclusively at the 1st Tyr of the Y-x-x-x-Y-Y motif

Structure

• homodimer.
• N-glycosylated
• belongs to the protein kinase superfamily, Tyr protein kinase family, insulin receptor subfamily
• contains 1 LDL-receptor class A domain
• contains 2 MAM domains
• contains 1 protein kinase domain

Compartment

membrane

Expression

• expressed in brain & CNS
• expressed weakly in small intestine, colon, prostate & testis

Pathology

• chromosomal translocation t(2;5)(p23;q35.1) involving ALK with NPM1 is found in a form of non-Hodgkin lymphoma
• chromosomal translocations t(2;11)(p23;p15) involving ALK with CARS & t(2;4)(p23;q21) involving ALK with SEC31A are associated with inflammatory myofibroblastic tumors
• chromosomal translocation t(2;17)(p23;q25) involving ALK with ALO17 is associated with anaplastic large-cell lymphoma

More general terms

• tyrosine kinase receptor (RTK)
• CD antigen
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:238
• OMIM: https://mirror.omim.org/entry/105590
• UniProt: http://www.uniprot.org/uniprot/Q9UM73.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=238