cysteinyl tRNA synthetase (cysteine-tRNA ligase, CysRS, CARS)

Function

-..........-

ATP + L-cysteine + tRNA(cys)
          <-->
AMP + diphosphate + L-cysteinyl-tRNA(cys)

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

• monomer (putative)
• belongs to the aminoacyl-tRNA synthetase-1 family

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Pathology

• chromosomal translocation t(2;11)(p23;p15) involving CARS with ALK is associated with inflammatory myofibroblastic tumors

More general terms

• amino acyl tRNA synthetase-1
• phosphoprotein

Additional terms

• cysteine-tRNA ligase, mitochondrial; mitochondrial Cysteinyl-tRNA synthetase; CysRS (CARS2)

Database

• OMIM: https://mirror.omim.org/entry/123859
• UniProt: http://www.uniprot.org/uniprot/P49589.html