pleiotrophin; PTN; heparin-binding brain mitogen; HBBM; heparin-binding growth factor 8; HBGF-8; heparin-binding growth-associated molecule; HB-GAM; heparin-binding neurite outgrowth-promoting factor 1; HBNF-1; osteoblast-specific factor 1; OSF-1 (PTN HBNF1 NEGF1)

Function

• secreted growth factor
• induces neurite outgrowth
• mitogenic for fibroblasts, epithelial, & endothelial cells
• binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN & regulation of cell proliferation
• phosphorylated by NEK6
• interacts with ALK & NEK6

Structure

belongs to the pleiotrophin family

Compartment

secreted

Expression

• expressed in osteoblasts & in brain
• induced by heparin & retinoic acid

More general terms

• secreted protein
• growth factor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5764
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5764
• OMIM: https://mirror.omim.org/entry/162095
• UniProt: http://www.uniprot.org/uniprot/P21246.html