phospholipid scramblase 3; PL scramblase 3; Ca+2-dependent phospholipid scramblase 3 (PLSCR3)

Function

• may facilitate ATP-independent bidirectional transbilayer migration of phospholipids upon binding Ca+2, resulting in a loss of phospholipid asymmetry in the plasma membrane
• role in the initiation of fibrin clot formation (putative)
• role in activation of mast cells (putative)
• role in recognition of apoptotic & injured cells by the reticuloendothelial system (putative)
• interacts with PDCD6 (Ca+2-dependent)

Cofactor: Ca+2 (putative)

Structure

• belongs to the phospholipid scramblase family

Compartment

• membrane; single-pass type 2 membrane protein (putative)

Expression

• expressed in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine & peripheral blood lymphocytes
• not expressed in testis, brain & liver

More general terms

• phospholipid scramblase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57048
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57048
• OMIM: https://mirror.omim.org/entry/607611
• UniProt: http://www.uniprot.org/uniprot/Q9NRY6.html