charged multivesicular body protein 4A; chromatin-modifying protein 4a; CHMP4a; SNF7 homolog associated with Alix-2; SNF7-1; hSnf-1; vacuolar protein sorting-associated protein 32-1; Vps32-1; hVps32-1 (CHMP4A, C14orf123, SHAX2, CDA04, HSPC134)

Function

• component of ESCRT3 in the multivesicular body pathway
• within ESCRT3, serves as an acceptor for ESCRT1 complex
• interacts with CHMP2A, CHMP4B, CHMP4C, CHMP6 within ESCRT3
• interacts with ESCRT1 component PDCD6IP
• self-associates
• overexpression leads to the assembly of filaments that curve & associate to create circular rings that can promote outward budding
• interacts with VPS4A

Structure

• the acidic C-terminus & the basic N-termminus are thought to render the protein in a closed, soluble & inactive conformation through an autoinhibitory intramolecular interaction
• the open & active conformation, which enables membrane binding & oligomerization, is facilitated by interaction with other ESCRT components (putative)
• belongs to the SNF7 family

Compartment

• cytoplasmic, membrane-associated
• localizes to large vesicle-like structures
• localizes to the midbody of dividing cells
• localized in two distinct rings on either side of the midbody

Expression

• widely expressed
• expressed in heart, kidney, liver, skeletal muscle > brain, placenta, lung, pancreas

Pathology

• role in HIV-1 virus release via its interaction with PDCD6IP

More general terms

• charged multivesicular body protein (CHMP)

Component of

• endosomal sorting complex required for transport-3 (ESCRT3)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=29082
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:29082
• OMIM: https://mirror.omim.org/entry/610051
• UniProt: http://www.uniprot.org/uniprot/Q9BY43.html