charged multivesicular body protein 6; chromatin-modifying protein 6; vacuolar protein sorting-associated protein 20; Vps20; hVps20 (CHMP6, VPS20)

Function

• component of ESCRT3 in the multivesicular body pathway
• In the ESCRT3 complex, serves as an acceptor for ESCRT2 on endosomal membranes
• interacts with CHMP4A, CHMP4B, CHMP4C within ESCRT3
• interacts with SNF8, VPS25, VPS36 of ESCRT2
• interacts with VPS4A & VPS4B

Structure

• the acidic C-terminus & the basic N-termminus are thought to render the protein in a closed, soluble & inactive conformation through an autoinhibitory intramolecular interaction
• the open & active conformation, which enables membrane binding & oligomerization, is achieved by interaction with other ESCRT components
• belongs to the SNF7 family

Compartment

• endomembrane system, late endosome membrane, lipid-anchor

Expression

ubiquitously expressed

More general terms

• charged multivesicular body protein (CHMP)
• myristoylated protein

Component of

• endosomal sorting complex required for transport-3 (ESCRT3)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79643
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79643
• OMIM: https://mirror.omim.org/entry/610901
• UniProt: http://www.uniprot.org/uniprot/Q96FZ7.html