vacuolar protein sorting-associated protein 4B (suppressor of K+ transport growth defect 1, protein SKD1,VPS4B, SKD1, VPS42)
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Function
- intracellular protein transport via prevacuolar endosome
- release of components of the bilayered coat from the endosomal membrane
- association with ESCRT3 complex mediates ATP-dependent disassembly of the ESCRT3 complex
- interacts with ESCRT3 complex components CHMP1A, CHMP1B & CHMP2A
- forms a heteromeric complex with VPS4A
Compartment
Expression
ubiquitously expressed
Pathology
- HIV-1 virus takes advantage of VPS4B for budding & exocytic cargos of viral proteins