charged multivesicular body protein 1B; CHMP1.5; chromatin-modifying protein 1B; CHMP1b; vacuolar protein sorting-associated protein 46-2; Vps46-2; hVps46-2 (CHMP1B, C18orf2)

Function

• component of ESCRT3 in the multivesicular body pathway
• in the ESCRT3 complex, it interacts directly with CHMP1A
• mediates ATP-dependent disassembly of ESCRT3 via interaction with VPS4A & VPS4B
• interacts with spastin, IST1, MITD1, STAMBP

Structure

belongs to the SNF7 family

Compartment

• cytoplasm, endosome
• localizes to the midbody of dividing cells, colocalizing with CEP55 & CHMP5
• localized at the periphery of the midbody

Expression

• widely expressed: pancreas, kidney, skeletal muscle, liver, lung, placenta, brain

Pathology

• involved in HIV-1 p6- & p9-dependent virus release

More general terms

• charged multivesicular body protein (CHMP)

Component of

• endosomal sorting complex required for transport-3 (ESCRT3)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57132
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57132
• OMIM: https://mirror.omim.org/entry/606486
• UniProt: http://www.uniprot.org/uniprot/Q7LBR1.html