centrosome protein 55; up-regulated in colon cancer 6 (CEP55, C10orf3, URCC6)
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Function
- mitotic exit
- cytokinesis
- Not required for microtubule nucleation
- hierachy of phosphorylation, where both Ser-425 & Ser-428 are phosphorylated at the onset of mitosis, prior to phosphorylation of Ser-436.
- phosphorylation at Ser-425 & Ser-428 required for dissociation from centrosome at G2/M boundary.
- phosphorylation at the 3 sites, Ser-425, Ser-428 & Ser-436, is required for completion of cytokinesis
- interacts with centrosome components rather than with microtubules.
- interacts with PLK1 when phosphorylated on Ser-425 & Ser-428
- interacts with AKAP9 & PCNT during interphase
Compartment
- present at the centrosomes at interphase
- during mitosis, phosphorylation-dependent dissociation from centrosome
Alternative splicing
named isoforms=2
Expression
- widely expressed, mostly in proliferative tissues
- highly expressed in testis > fetal thymus, cancer cell lines > digestive tract, bone marrow, lymph nodes, placenta, fetal heart, fetal spleen
- very low levels in expressed in brain