charged multivesicular body protein 5; chromatin-modifying protein 5; SNF7 domain-containing protein 2; vacuolar protein sorting-associated protein 60; Vps60; hVps60 (CHMP5, C9orf83, SNF7DC2, CGI-34, HSPC177, PNAS-11,4 PNAS-2)

Function

• component of ESCRT3 in the multivesicular body pathway
• interacts with CHMP2A
• interacts with VTA1
  • interaction involves soluble CHMP5
• interacts with SBP1

Structure

belongs to the SNF7 family

Compartment

• cytoplasm, endosome membrane
• localizes to the midbody of dividing cells
• localized in two distinct rings on either side of the midbody

Alternative splicing

named isoforms=2

More general terms

• charged multivesicular body protein (CHMP)
• phosphoprotein

Component of

• endosomal sorting complex required for transport-3 (ESCRT3)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51510
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:51510
• OMIM: https://mirror.omim.org/entry/610900
• UniProt: http://www.uniprot.org/uniprot/Q9NZZ3.html