vacuolar protein sorting-associated protein 4A; protein SKD2; hVPS4; VPS4-1 (VPS4A, VPS4)

Function

• intracellular protein transport via prevacuolar endosome
• release of components of the bilayered coat from the endosomal membrane
• association with ESCRT3 complex mediates ATP-dependent disassembly of the ESCRT3 complex
• interacts with ESCRT3 complex components CHMP1A, CHMP1B & CHMP2A
• forms a heteromeric complex with VPS4B

Compartment

• pre-vacuolar compartment, endosome, peripheral membrane

Expression

ubiquitously expressed

Pathology

• HIV-1 virus takes advantage of VPS4B for budding & exocytic cargos of viral proteins

More general terms

• vacuolar protein sorting-associated protein (VPS)
• protein subunit

Database

• UniProt: http://www.uniprot.org/uniprot/Q9UN37.html