vacuolar protein sorting-associated protein 36 (VPS36, ELL-associated protein of 45 kD, C13orf9, EAP45, CGI-145)

Function

• component of the ESCRT-2 complex
• interacts directly with CHMP6
• binds ubiquitin & phosphoinosides such as PtdIns(3,4,5)P3
• component of a complex at least composed of ELL, SNF8/EAP30, VPS25/EAP20 & VPS36/EAP45

Compartment

• cytoplasm, late endosome, nucleus
• colocalizes with ubiquitinated proteins on late endosomes

Alternative splicing

named isoforms=2

More general terms

• vacuolar protein sorting-associated protein (VPS)

Database

• UniProt: http://www.uniprot.org/uniprot/Q86VN1.html