synaptojanin-1; synaptic inositol-1,4,5-trisphosphate 5-phosphatase 1 (SYNJ1, KIAA0910)

Function

• inositol 5-phosphatase
• role in clathrin- mediated endocytosis
• binds AMPH, SH3GL1, SH3GL2 & SH3GL3

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate

Structure

• binds to EPS15 (a clathrin coat-associated protein) via a C-terminal domain containing three Asn-Pro-Phe (NPF) repeats
• the C-terminal proline-rich region mediates binding to a variety of SH3 domain-containing proteins including AMPH, SH3GL1, SH3GL2, SH3GL3 & GRB2
• belongs to the synaptojanin family
• in the central section; belongs to the inositol-1,4,5-trisphosphate 5-phosphatase family
• contains 1 RRM domain (RNA recognition motif)
• contains 1 SAC domain

Compartment

cytoplasm (putative)

Alternative splicing

named isoforms=4

Expression

• concentrated at clathrin-coated endocytic intermediates in nerve terminals
• isoform 1 is more enriched than isoform 2 in developing brain as well as non-neuronal cells
• isoform 2 is very abundant in nerve terminals

More general terms

• phosphomonoesterase
• RNA-binding protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8867
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8867
• OMIM: https://mirror.omim.org/entry/604297
• UniProt: http://www.uniprot.org/uniprot/O43426.html