follicle-stimulating hormone primary response protein: FSH primary response protein 1; leucine-rich primary response protein 1 (FSHPRH1, LRPR1, CENPI)

Function

• component of the CENPA-CAD (nucleosome distal) complex,
• may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex
• required for the localization of CENPF, MAD1L1 & MAD2 (MAD2L1 or MAD2L2) to kinetochores
• role in response of gonadal tissues to FSH
• sumoylated by RNF4, leading to its degradation
• desumoylated by SENP6, preventing its degradation
• interacts with SENP6

Structure

belongs to the mis6 family

Compartment

• nucleus, chromosome, centromere
• localizes exclusively in the centromeres
• the CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex

Alternative splicing

named isoforms=2

Expression

• induction by follicle-stimulating hormone (FSH)

Pathology

• X-linked disorders of gonadal development & gametogenesis

More general terms

• phosphoprotein

Component of

• CENPA-CAD (nucleosome distal) complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2491
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2491
• OMIM: https://mirror.omim.org/entry/300065
• UniProt: http://www.uniprot.org/uniprot/Q92674.html