caspase recruitment domain-containing protein 18; caspase-1 inhibitor Iceberg (CARD18, ICEBERG, UNQ5804/PRO19611)

Function

• inhibits generation of IL-1-beta by interacting with caspase-1 & preventing its association with RIP2
• down-regulates release of IL1B
• interacts with pro-CASP1
• interacts with CARD8

Structure

• member of death domain-fold superfamily
• contains 1 CARD domain

Expression

• primarily expressed in the heart & placenta
• up-regulated in response to TNF & bacterial lipopolysaccharide (LPS)

More general terms

• protease inhibitor
• caspase recruitment domain protein (CARD protein)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=59082
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:59082
• OMIM: https://mirror.omim.org/entry/605354
• UniProt: http://www.uniprot.org/uniprot/P57730.html