Caspase recruitment domain-containing protein 8; apoptotic protein NDPP1; CARD-inhibitor of NF-kappa-B-activating ligand; CARDINAL; DACAR; tumor up-regulated CARD-containing antagonist of CASP9; TUCAN (CARD8 KIAA0955 NDPP1)

Function

• inhibits NF-kappa-B activation
  • may participate in a regulatory mechanism that coordinates cellular responses
  • controlled by NF-kappa-B transcription factor
  • may be a component of the inflammasome
  • may form homodimers
  • interacts with NEMO & DRAL
  • binds to caspase-1, CARD16/pseudo-ICE & CARD18/ICEBERG
  • interacts with FNBP3 (putative)
  • interacts with NALP2 NACHT domain

Structure

contains 1 CARD domain

Compartment

cytoplasm. nucleus

Alternative splicing

named isoforms=3

Expression

• high expression in lung, ovary, testis & placenta
• lower expression in heart, kidney & liver
• also expressed in spleen, lymph node & bone marrow

More general terms

• pro apoptotic protein

Additional terms

• apoptosis
• caspase; cysteinyl aspartate-specific proteinase; ICE/CED3 family protease

Component of

• inflammasome

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22900
• OMIM: https://mirror.omim.org/entry/609051
• UniProt: http://www.uniprot.org/uniprot/Q9Y2G2.html