pre-mRNA-processing factor 40 homolog A (formin-binding protein 3, formin-binding protein 11, huntingtin-interacting protein HYPA, huntingtin yeast partner A, Fas ligand-associated factor 1, NY-REN-6 antigen, PRPF40A, FBP11, FLAF1, FNBP3, HYPA, HSPC225)
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Function
- binds to WASL/N-WASP & suppresses its translocation from nucleus to cytoplasm, thus inhibiting its cytoplasmic function
- role in pre-mRNA splicing (putative)
- interacts with N-terminus of huntingtin
- interacts with phosphorylated carboxyterminal domain of POLR2A
- interacts with SF1, SRPK1 CARD8, ATBF1 & MECP2
- interacts through the WW domains with formin proline-rich regions & with WASL/N-WASP
Structure
- contains 5 FF domains
- contains 2 WW domains WW domains are essential for localization to nuclear speckles
Compartment
Alternative splicing
named isoforms=4
Expression
widely expressed