NACHT, LRR & PYD-containing protein 2; PYRIN domain & NACHT domain-containing protein 1; PYRIN-containing APAF1-like protein 2; nucleotide-binding site protein 1 (NALP2, NLRP2, NBS1, PAN1, PYPAF2)
Jump to navigation
Jump to search
Function
- suppresses TNF- & CD40-induced NFKB1 activity via IKK complex, by inhibiting NFKBIA degradation induced by TNF
- when associated with PYCARD, activates CASP1, leading to secretion of mature proinflammatory cytokine IL1B
- component of the inflammasome
- interacts with CHUK, IKBKB & IKBKG,
- interacts with PYCARD & DAPIN domain of NAPL1, but NOT full-length protein
- DAPIN domain is necessary & sufficient for suppression of NFKB1 activation induced by TNF & for inducing IL1B secretion in association with caspase-1
- DAPIN domain is involved in interaction with PYCARD
- isolated NACHT domain interacts with CARD8, but interaction not observed for full-length protein (autoinhibition?)
Structure
- contains 1 DAPIN domain contains 9 LRR repeats (leucine-rich repeats) contains 1 NACHT domain
Compartment
Alternative splicing
named isoforms=4
Expression
- expressed in lung, placenta, thymus > ovary, intestine, brain
- induced by interferons & lipopolysaccharide (LPS)