caspase-1 inhibitor COP; CARD only domain-containing protein 1; pseudo interleukin-1 beta converting enzyme; pseudo-ICE (COP1, COP, CARD16)

Function

• caspase inhibitor
• acts as a regulator of procaspase-1/CASP1 activation implicated in regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) & its release during inflammation
• inhibits the release of IL1B in response to LPS in monocytes
• also induces NF-kappa-B activation during the pro-inflammatory cytokine response
• also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, & staurosporine-mediated cell death but not ER stress-mediated cell death.
• acts by preventing activation of caspases CASP1 & CASP4, possibly by preventing the interaction between CASP1 & RIPK2

Structure

• homooligomer
• interacts with CASP1, CASP4, CARD8 & RIPK2
• contains 1 CARD domain

Alternative splicing

named isoforms=2

Expression

• widely expressed
• expressed at higher level in placenta, spleen, lymph node & bone marrow
• weakly or not expressed in thymus

Pathology

• down-regulated in patients with Huntington disease

More general terms

• protease inhibitor
• other protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1147
• UniProt: http://www.uniprot.org/uniprot/Q5EG05.html