caspase recruitment domain-containing protein 9; hCARD9 (CARD9)

Function

• activates NF-kappa-B via BCL10
• self-associates
• CARD9 & BCL10 bind to each other by CARD-CARD interaction

Structure

contains 1 CARD domain

Compartment

cytoplasm

Alternative splicing

named isoforms=3

Expression

• highly expressed in spleen
• also detected in liver, placenta, lung, peripheral blood leukocytes & in brain

Pathology

• defects in CARD9 are the cause of familial candidiasis type 2

More general terms

• caspase recruitment domain protein (CARD protein)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64170
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:64170
• OMIM: https://mirror.omim.org/entry/212050
• OMIM: https://mirror.omim.org/entry/607212
• UniProt: http://www.uniprot.org/uniprot/Q9H257.html