caspase recruitment domain-containing protein 14; CARD-containing MAGUK protein 2; carma 2 (CARD14, CARMA2)

Function

• activates NF-kappa-B via BCL10 & IKK
• stimulates phosphorylation of BCL10
• CARD14 & BCL10 bind to each other by CARD-CARD interaction

Structure

• contains 1 CARD domain
• contains 1 guanylate kinase-like domain
• contains 1 PDZ domain (DHR domain)

Compartment

cytoplasm

Expression

• expressed in placenta
• also detected in HeLa S3 cells, but not in the other cancer cell lines tested

More general terms

• caspase recruitment domain protein (CARD protein)
• phosphoprotein
• human longevity protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79092
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79092
• OMIM: https://mirror.omim.org/entry/607211
• UniProt: http://www.uniprot.org/uniprot/Q9BXL6.html