elongator complex protein 1; ELP1; IkappaB kinase complex-associated protein; IKK complex-associated protein; p150 (IKBKAP, ELP1, IKAP, DYS)

Function

• may act as a scaffold protein that may assemble active IkB kinase complex & MAP3K14 complex
• subunit of the RNA polymerase 2 elongator complex, thus may play a role in chromatin remodeling & acetylation of histones H3 & H4
• interacts preferentially with MAP3K14/NIK followed by IKK-alpha & IKK-beta
• associates with the C-terminal domain (CTD) of POLR2A
• interacts with ELP3
• phosphorylated

Structure

belongs to the ELP1/IKA1 family

Compartment

cytoplasm. nucleus

Pathology

• defects in IKBKAP are the cause of familial dysautonomia (Riley-Day syndrome)

More general terms

• phosphoprotein

Component of

• IkB kinase complex
• RNA polymerase 2 elongator complex

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8518
• OMIM: https://mirror.omim.org/entry/223900
• OMIM: https://mirror.omim.org/entry/603722
• UniProt: http://www.uniprot.org/uniprot/O95163.html