diablo homolog, mitochondrial; second mitochondria-derived activator of caspase; smac protein; direct IAP-binding protein with low pI (DIABLO, SMAC)

Function

• promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway
• released from mitochondria with cytochrome c during apoptosis
• associates with complex containing APAF
• acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP)
• interacts with NGFRAP1/BEX3 (putative)
• interacts with BIRC2, BIRC3, XIAP & BIRC7

Structure

• homodimer
• the mature N-terminus mediates interaction with XIAP

Compartment

• mitochondria
• released into the cytosol when cells undergo apoptosis

Alternative splicing

named isoforms=2

Expression

• ubiquitously expressed with highest expression in testis
• expression is also high in heart, liver, kidney, spleen, prostate & ovary
• low expresion in brain, lung, thymus & peripheral blood leukocytes

More general terms

• mitochondrial protein

Additional terms

• apoptotic protease-activating factor 1; APAF-1 (APAF1, KIAA0413)
• Baculoviral IAP repeat-containing protein 4; E3 ubiquitin-protein ligase XIAP; inhibitor of apoptosis protein 3; X-linked inhibitor of apoptosis protein; X-linked IAP; IAP-like protein; HILP (XIAP, API3, BIRC4, IAP3)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=56616
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:56616
• OMIM: https://mirror.omim.org/entry/605219
• UniProt: http://www.uniprot.org/uniprot/Q9NR28.html