protein BEX3; brain-expressed X-linked protein 3; p75NTR-associated cell death executor; nerve growth factor receptor-associated protein 1; ovarian granulosa cell 13.0 kD protein HGR74 (NGFRAP1, BEX3, DXS6984E, NADE)

Function

• may be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF
• plays a role in Zn+2-triggered neuronal death (putative)
• may play an important role in the pathogenesis of neurogenetic diseases
• ubiquitinated
• degraded by the proteasome (putative)
• self-associates
• interacts with 14-3-3 epsilon (YWHAE)
• interacts with DIABLO/SMAC (putative)
• binds to the DEATH
• domain of p75NTR/NGFR

Structure

the nuclear export signal is required for export from the nucleus & the interactions with itself & p75NTR/NGFR (By similarity) belongs to the BEX family

Compartment

nucleus. cytoplasm. Note: shuttles between the cytoplasm & the nucleus. associates with replicating mitochondria (putative)

Expression

found in ovarian granulosa cells, testis, prostate & seminal vesicle tissue. high levels also detected in liver

Notes

binds transition metals (putative)

More general terms

• nuclear protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q00994.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27018
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27018
• OMIM: https://mirror.omim.org/entry/300361