baculoviral IAP repeat-containing protein 7; kidney inhibitor of apoptosis protein; KIAP; melanoma inhibitor of apoptosis protein; ML-IAP; livin; RING finger protein 50 (BIRC7; KIAP; LIVIN; MLIAP; RNF50, UNQ5800/PRO19607/PRO21344)

Function

• protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine
• suppression of apoptosis is mediated by activation of MAPK8/JNK1, & possibly also of MAPK9/JNK2; activation depends on TAB1 & NR2C2/TAK1
• in vitro, inhibits caspase-3 & proteolytic activation of pro-caspase-9
• isoform 1 blocks staurosporine-induced apoptosis
• isoform 2 blocks etoposide-induced apoptosis
• binds to caspase-9
• interaction with SMAC via the BIR domain disrupts binding to caspase-9 & apoptotic suppressor activity
• interacts with TAB1
• in vitro, interacts with caspase-3 & caspase-7 via its BIR domain

Structure

• belongs to the IAP family
• contains 1 BIR repeat
• contains 1 RING-type Zn+2 finger

Compartment

• nucleus, cytoplasm
• nuclear, & in a filamentous pattern throughout the cytoplasm

Alternative splicing

named isoforms=2

Expression

• very low levels or not detectable in most adult tissues
• detected in adult heart, placenta, lung, lymph node, spleen & ovary, & in several carcinoma cell lines (isoform 1 & isoform 2)
• isoform 2 (but not isoform 1) is detected in fetal kidney, heart & spleen, & at lower levels in adult brain, skeletal muscle & peripheral blood leukocytes

More general terms

• inhibitor of apoptosis protein
• nuclear protein
• ring finger protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=79444
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:79444
• OMIM: https://mirror.omim.org/entry/605737
• UniProt: http://www.uniprot.org/uniprot/Q96CA5.html