transcription factor HIVEP3 (Human immunodeficiency virus type I enhancer-binding protein 3, Kappa-B & V(D)J recombination signal sequences-binding protein, zinc finger protein ZAS3, Kappa-binding protein 1, KBP-1) (HIVEP3 KBP1 KIAA1555 KRC ZAS3)
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Function
- plays a role of transcription factor
- binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin & T-cell receptor gene segments
- also binds to the kappa-B motif of genes such as S100A4
- role in cell progression & differentiation
- involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells
- strongly inhibits TNF-alpha-induced NF-kappa-B activation
- interferes with nuclear factor NF-kappa-B by several mechanisms:
- as transcription factor
- by competing for Kappa-B motif
- by repressing transcription in the nucleus
- through non transcriptional process
- by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks formation of IKK complex
- interaction with TRAF proteins inhibits both NF-Kappa-B mediated & c-Jun N-terminal kinase/JNK mediated responses, including apoptosis & proinflammatory cytokine gene expression
- positively regulates expression of IL2 in T-cells
- role in adult bone formation
- interacts with TRAF1 & TRAF2 as well as with JUN
- forms multimeric complex with RUNX2 & E3 ubiquitin ligase WWP1
- phosphorylated on threonine & serine residues
Structure
- the ZAS2 domain binds DNA as dimers, tetramers, & multiple of tetramers & readily forms highly ordered DNA-protein structures (putative)
- contains 5 C2H2-type Zn+2-fingers
Compartment
Alternative splicing
named isoforms=2 Additional isoforms can be generated by alternative splicing or polyadenylation. HIVEP3L transcript may lack exon 7 leading to a premature codon stop
Expression
induced by TPA