NFATC2-interacting protein (nuclear factor of activated T-cells - cytoplasmic 2-interacting protein, 45 kD NFAT-interacting protein, 45 kD NF-AT-interacting protein, NFATC2IP, NIP45)

Function

• role in inducible expression of cytokine genes in T-cells, especially by increasing NFAT-driven IL-4 production
• interacts with NFATC2, TRAF1, TRAF2 & PRMT
• methylation at the N-terminus by PRMT1 modulates interaction with the NFAT complex & results in augmented cytokine production

Structure

contains 1 ubiquitin-like domain

Compartment

• nucleus, cytoplasm
• TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm & prevents its translocation to the nucleus

Alternative splicing

named isoforms=3

More general terms

• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8NCF5.html