tumor necrosis factor receptor superfamily member 19L; receptor expressed in lymphoid tissues (RELT, TNFRSF19L)

Function

• mediates activation of NF-kappa-B
• may play a role in T-cell activation
• associates with TRAF1
• interacts with RELL1, RELL2 & OXSR1
• phosphorylated in vitro by OXSR1

Structure

• belongs to the RELT family
• contains 1 TNFR-Cys repeat

Compartment

cell membrane, cytoplasm

Expression

• highest levels are in spleen, lymph node, thymus, peripheral blood leukocytes, bone marrow & fetal liver
• very low levels in skeletal muscle, testis & colon
• not detected in brain, kidney & pancreas

More general terms

• tumor necrosis factor [TNF] receptor family
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8495
• OMIM: https://mirror.omim.org/entry/611211
• UniProt: http://www.uniprot.org/uniprot/Q969Z4.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84957