CD134; tumor necrosis factor receptor superfamily member 4; OX40L receptor; ACT35 antigen; TAX transcriptionally-activated glycoprotein 1 receptor (TNFRSF4, TXGP1L)

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^[1]^[2]^[3]^[4]

Function

receptor for TNFSF4/OX40L/GP34
interacts with TRAF2, TRAF3 & TRAF5
promotes bcl-xL & bcl-2 & suppresses apoptosis in CD4 T cells^[4]

Structure

contains 4 TNFR-cys repeats

Compartment

membrane

Pathology

implicated in pathogenesis of cytokine storm

Notes

rat T-cell antigen ox40/ACT35

More general terms

Additional terms

tumor necrosis factor ligand superfamily member 4; OX40 ligand; OX40L; glycoprotein Gp34; TAX transcriptionally-activated glycoprotein 1; CD252 (TNFSF4, TXGP1)

References

↑ UniProt http://www.uniprot.org/uniprot/P43489.html
↑ NIEHS-SNPs http://egp.gs.washington.edu/data/tnfrsf4/
↑ Taga T & Kishimoto T Cytokine receptors and signal transduction FASEB J 6:3387 1992 PMID: https://www.ncbi.nlm.nih.gov/pubmed/1334470
↑ ^4.0 ^4.1 Rogers PR, Song J, Gramaglia I, Killeen N, Croft M. OX40 promotes Bcl-xL and Bcl-2 expression and is essential for long-term survival of CD4 T cells. Immunity. 2001 Sep;15(3):445-55. PMID: https://www.ncbi.nlm.nih.gov/pubmed/11567634

Database

Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7293
OMIM: https://mirror.omim.org/entry/600315
UniProt: http://www.uniprot.org/uniprot/P43489.html
Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7293

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