cytokine storm; cytokine cascade; hypercytokinemia
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Introduction
severe case of cytokine release syndrome
Pathology
- potentially fatal positive feedback loop between cytokines & leukocytes
- renin angiotensin system has been implicated
Clinical manifestations
Management
- tocilizumab (Actemra) FDA-approved 8/2017
- investigational (potentially useful agents)
- targeting of OX40 & OX40L
- OX40 Ig
- simvastatin down-regulates OX40 & OX40L
- ACE inhibitor or ARB
- gemfibrozil
- TNF-alpha blockers
- targeting of OX40 & OX40L
More general terms
References
- ↑ Wikipedia: cytokine storm http://en.wikipedia.org/wiki/Cytokine_storm
- ↑ Gever J FDA Approves CAR T-Cell Therapy for Leukemia. 'First gene therapy available in the United States,' says agency. MedPage Today. August 30, 2017 https://www.medpagetoday.com/HematologyOncology/Leukemia/67615
FDA News Release. Aug 30, 2017 FDA approval brings first gene therapy to the United States. https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm574058.htm