tumor necrosis factor ligand superfamily member 4; OX40 ligand; OX40L; glycoprotein Gp34; TAX transcriptionally-activated glycoprotein 1; CD252 (TNFSF4, TXGP1)

Function

• cytokine that binds to TNFRSF4
• co-stimulates T-cell proliferation & cytokine production

Structure

• homotrimer
• belongs to the tumor necrosis factor family

Compartment

membrane; single-pass type 2 membrane protein

Expression

• induced by human T-cell leukemia virus type 1 transactivator P40-TAX

Pathology

• genetic variation in TNFSF4 influences susceptibility to systemic lupus erythematosus (SLE)

More general terms

• glycoprotein
• tumor necrosis factor (TNF) family protein
• CD antigen

Database

• UniProt: http://www.uniprot.org/uniprot/P23510.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7292
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7292
• OMIM: https://mirror.omim.org/entry/152700
• OMIM: https://mirror.omim.org/entry/603594