CD30; tumor necrosis factor receptor superfamily member 8; CD30L receptor; lymphocyte activation antigen CD30; KI-1 antigen (TNFRSF8, D1S166E)
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Function
- receptor for TNFSF8/CD30L
- may play a role in the regulation of cellular growth & transformation of activated lymphoblasts
- regulates gene expression through activation of NF-kappa-B
- interacts with TRAF1, TRAF2, TRAF3 & TRAF5
- phosphorylated on Ser & Tyr
Structure
Compartment
- isoform long: cell membrane
- isoform short: cytoplasm
Alternative initiation
named isoforms=2
Expression
- granulocytes
- plasma cells
- activated T cells & B cells
- NK cells
Pathology
- expressed in:
- lymphocytes infected with HIV, HTLV-1, EBV, HHV8 or hepatitis B virus
- infectious mononucleosis
- Reed-Sternberg cells
- CD30 is a cell surface marke for Hodgkin's disease
- anaplastic large cell lymphomas ~90%
- lymphomatoid papulosis
- peripheral T cell lymphomas
- embryonal carcinoma
Pharmacology
- target of monoclonal antibody brentuximab, component of antineoplastic agent brentuximab vedotin used for treatment of Hodgkin's lymphoma & systemic anaplastic large cell lymphoma
More general terms
Additional terms
References
- ↑ Durkop H et al, Molecular cloning and expression of a new member of the nerve growth factor receptor family that is chararteristic for Hodgkin's disease Cell 68:421-7 1992 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/1310894
- ↑ <Internet> http://www.pathologyoutlines.com/cdmarkers.html 15 October 2002
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=943
- ↑ UniProt http://www.uniprot.org/uniprot/P28908.html