CD30; tumor necrosis factor receptor superfamily member 8; CD30L receptor; lymphocyte activation antigen CD30; KI-1 antigen (TNFRSF8, D1S166E)

Function

• receptor for TNFSF8/CD30L
• may play a role in the regulation of cellular growth & transformation of activated lymphoblasts
• regulates gene expression through activation of NF-kappa-B
• interacts with TRAF1, TRAF2, TRAF3 & TRAF5
• phosphorylated on Ser & Tyr

Structure

contains 6 TNFR-Cys repeats

Compartment

• isoform long: cell membrane
• isoform short: cytoplasm

Alternative initiation

named isoforms=2

Expression

• granulocytes
• plasma cells
• activated T cells & B cells
• NK cells

Pathology

• expressed in:
  • lymphocytes infected with HIV, HTLV-1, EBV, HHV8 or hepatitis B virus
  • infectious mononucleosis
  • Reed-Sternberg cells
    • CD30 is a cell surface marke for Hodgkin's disease
  • anaplastic large cell lymphomas ~90%
  • lymphomatoid papulosis
  • peripheral T cell lymphomas
  • embryonal carcinoma

Pharmacology

• target of monoclonal antibody brentuximab, component of antineoplastic agent brentuximab vedotin used for treatment of Hodgkin's lymphoma & systemic anaplastic large cell lymphoma

More general terms

• tumor necrosis factor [TNF] receptor family
• CD antigen

Additional terms

• Hodgkin's disease (Hodgkin's lymphoma)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:943
• OMIM: https://mirror.omim.org/entry/153243
• UniProt: http://www.uniprot.org/uniprot/P28908.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=943