lymphotoxin alpha/beta receptor; tumor necrosis factor receptor superfamily member 3; lymphotoxin-beta receptor; tumor necrosis factor receptor 2-related protein; tumor necrosis factor C receptor (LTBR, D12S370, TNFCR, TNFRSF3)

Function

• receptor for the heterotrimeric lymphotoxin containing LTA & LTB, & for TNFS14/LIGHT
• promotes apoptosis via TRAF3 & TRAF5
• may play a role in development of lymphoid organs
• self-associates
• associates with TRAF3, TRAF4 & TRAF5
• interacts with HCV core protein

Structure

contains 4 TNFR-cys repeats

Compartment

membrane

More general terms

• tumor necrosis factor [TNF] receptor family
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4055
• OMIM: https://mirror.omim.org/entry/600979
• UniProt: http://www.uniprot.org/uniprot/P36941.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4055