TRAF3-interacting protein 1 (microtubule-interacting protein associated with TRAF3, MIP-T3, interleukin 13 receptor alpha 1-binding protein 1, TRAF3IP1, MIPT3)

Function

• inhibitory role on IL13 signaling by binding to IL13RA1
• involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity & DNA-binding
• recruits TRAF3 & DISC1 to the microtubules
• interacts with IL13RA1
• binds to microtubules, TRAF3 & DISC1

Structure

belongs to the TRAF3IP1 family

Compartment

• cytoplasm, cytoskeleton, microtubules

Alternative splicing

named isoforms=2

Expression

ubiquitous

More general terms

• microtubule-associated protein (MAP)
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/607380
• UniProt: http://www.uniprot.org/uniprot/Q8TDR0.html