CD213a1; interleukin-13 receptor alpha-1; IL-13R-alpha-1; IL-13RA-1; cancer/testis antigen 19; CT19; CD213a1 (IL13RA1, IL13R, IL13RA)

Function

• binds IL13 with a low affinity
• together with IL4R-alpha can form a functional IL-13 receptor for IL-13
• also serves as an alternate accessory protein to the common cytokine receptor gamma chain for IL4 signaling
• interacts with TRAF3IP1

Structure

• the WSXWS motif appears to be necessary for proper protein folding, efficient intracellular transport & cell- surface receptor binding
• the box 1 motif is required for JAK interaction &/or activation
• belongs to the type I cytokine receptor family, type 5 subfamily

Compartment

membrane

Expression

• ubiquitous
• highest levels in heart, liver, skeletal muscle & ovary
• lowest levels in brain, lung & kidney
• also found in B-cells, T-cells & endothelial cells

More general terms

• CD antigen
• protein subunit
• glycoprotein

Component of

• interleukin-13 receptor (IL13 receptor)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3597
• OMIM: https://mirror.omim.org/entry/300119
• UniProt: http://www.uniprot.org/uniprot/P78552.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3597