tumor necrosis factor ligand superfamily member 14; Herpes virus entry mediator ligand; HVEM-L; CD258 (TNFSF14, HVEML, LIGHT, UNQ391/PRO726)

Function

• cytokine that binds to TNFRSF3/LTBR
• binding to the decoy receptor TNFRSF6B modulates its effects
• activates NFKB, stimulates the proliferation of T-cells, & inhibits growth of the adenocarcinoma HT-29
• the soluble form of isoform 1 derives from the membrane form by proteolytic processing

Structure

• homotrimer
• N-glycosylated
• belongs to the tumor necrosis factor family

Compartment

• cell membrane; single-pass type 2 membrane protein
• soluble & membrane forms
• isoform 2: cytoplasm

Alternative splicing

named isoforms=2

Expression

• predominantly expressed in the spleen
• also found in the brain
• weakly expressed in peripheral lymphoid tissues & in heart, placenta, liver, lung, appendix, & kidney,
• no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines
• up-regulated after T-cell activation

Pathology

• acts as a receptor for Herpes simplex virus

More general terms

• tumor necrosis factor (TNF) family protein
• CD antigen

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8740
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8740
• OMIM: https://mirror.omim.org/entry/604520
• UniProt: http://www.uniprot.org/uniprot/O43557.html