CD272; B- & T-lymphocyte attenuator; B- & T-lymphocyte-associated protein (BTLA)

Function

• lymphocyte inhibitory receptor
• inhibits lymphocytes during immune response
• interacts with PTPN6/SHP-1, PTPN11/SHP-2, TNFRSF14/HVEM
• phosphorylated by TNFRSF14

Structure

• N-glycosylated
• contains 1 Ig-like V-type domain

Compartment

• single-pass type 1 membrane protein (putative)

Alternative splicing

named isoforms=2

More general terms

• CD antigen
• glycoprotein
• phosphoprotein
• receptor

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=151888
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:151888
• OMIM: https://mirror.omim.org/entry/607925
• UniProt: http://www.uniprot.org/uniprot/Q7Z6A9.html