ubiquitin carboxyl-terminal hydrolase 48 (ubiquitin thioesterase 48, ubiquitin-specific-processing protease 48, deubiquitinating enzyme 48, USP48, USP31)

Function

• recognizes & hydrolyzes peptide bond at the C-terminal Gly of ubiquitin
• role in processing of ubiquinated proteins & poly-ubiquitin precursors
• role in regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA & TRAF2
• regulatory role at post-synaptic sites (putative)

Ubiquitin C-terminal thioester + H2O <--> ubiquitin + a thiol

Structure

• belongs to the peptidase C19 family
• contains 3 DUSP domains
• contains 1 ubiquitin-like domain

Compartment

cytoplasm, nucleus

Alternative splicing

named isoforms=7

Expression

widely expressed

More general terms

• ubiquitin C-terminal hydrolase
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q86UV5.html