interleukin-15 [IL-15] receptor-alpha; IL-15R-alpha; IL-15RA; sIL-15R-alpha; sIL-15RA (IL15RA)

Function

• receptor for interleukin-15
• signal transduction involves STAT3, STAT5, STAT6, JAK2 & SYK
• isoforms 6,7,8,9 do NOT bind IL-15
• phosphorylated by activated SYK
• soluble form sIL-15R-alpha binds IL-15, thus interferes with IL-15 binding to the membrane receptor

Structure

• N & O-glycosylated
• contains 1 Sushi (CCP/SCR) domain

Compartment

• mainly found associated with the nuclear membrane
• isoforms 6,7,8,9: endoplasmic reticulum membrane, Golgi, cytoplasmic vesicle membrane
• a soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor; cleavage involves ADAM17

Alternative splicing

named isoforms=9

Expression

• expression of different isoforms may alter or interfere with signal transduction
• isoforms 1,3,4,5,6,7,8,9 are widely expressed

More general terms

• protein subunit
• membrane protein
• phosphoprotein
• glycoprotein

Additional terms

• interleukin-15 (IL15, IL-15)

Component of

• interleukin-15 receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3601
• OMIM: https://mirror.omim.org/entry/601070
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3601
• UniProt: http://www.uniprot.org/uniprot/Q13261.html