CD27, CD27L receptor, TNF receptor family, member 7 (TNFRSF7) or T-cell activation antigen T4

Function

• receptor for CD70
• may play role in differentiation & survival of activated T cells, also B cell proliferation
• interacts with SIVA1 & TRAF2

Structure

• homodimer.
• contains 3 TNFR-Cys repeats

Compartment

membrane

Expression

• T cells, memory B cells

Laboratory

• marker for T cell activation

More general terms

• tumor necrosis factor [TNF] receptor family
• CD antigen
• phosphoprotein
• glycoprotein

Additional terms

• CD70 antigen; CD27 ligand; CD27-L; tumor necrosis factor ligand superfamily member 7 (CD70, CD27L, CD27LG, TNFSF7)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:939
• OMIM: https://mirror.omim.org/entry/186711
• UniProt: http://www.uniprot.org/uniprot/P26842.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=939