CD70 antigen; CD27 ligand; CD27-L; tumor necrosis factor ligand superfamily member 7 (CD70, CD27L, CD27LG, TNFSF7)

Function

• CD27L is the ligand for CD27
• role in T-cell activation
• induces proliferation of costimulated T-cells
• enhances generation of cytolytic T-cells
• in connection with fasL & CD27L on the surface of Th1 cells, & MHC class 1 antigen complex on Ag-presenting cells, fas, CD27 & the T-cell receptor stimulate cytotoxic T-cell maturation

Structure

• homotrimer (probable)
• belongs to the tumor necrosis factor family

Compartment

• membrane; single-pass type 2 membrane protein

Expression

• activated B & T cells
• expressed on T helper-1 cells (Th1)
• Reed-Sternberg cells

More general terms

• CD antigen
• tumor necrosis factor (TNF) family protein

Additional terms

• CD27, CD27L receptor, TNF receptor family, member 7 (TNFRSF7) or T-cell activation antigen T4

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=970
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:970
• OMIM: https://mirror.omim.org/entry/602840
• UniProt: http://www.uniprot.org/uniprot/P32970.html