CASP8-associated protein 2 (FLICE-associated huge protein, CASP8AP2, FLASH, KIAA1315, RIP25)

Function

• role in TNF-alpha-induced blockade of glucocorticoid receptor transactivation at the nuclear receptor coactivator level, upstream & independently of NF-kappa-B
• suppresses both NCOA2- & NCOA3-induced enhancement of glucocorticoid receptor transactivation
• role in TNF-alpha-induced activation of NF-kappa-B (TRAF2- dependent)
• role as downstream mediator for CASP8-induced activation of NF-kappa-B
• required for activation of CASP8 in FAS-mediated apoptosis
• self-associates
• component of the death-inducing signaling complex
• interacts with NCOA2, NCOA3 & TRAF2

Compartment

cytoplasm, nucleus

Expression

• induced by TNF-alpha, which induces nuclear localization

More general terms

• other protein

Component of

• death-inducing signaling complex (DISC)

Database

• OMIM: https://mirror.omim.org/entry/606880
• UniProt: http://www.uniprot.org/uniprot/Q9UKL3.html