phosphatidylinositol-4-phosphate 5-kinase type-1 alpha; PIP5K1-alpha; Ptdins(4)P-5-kinase 1 alpha; 68 kD type 1 phosphatidylinositol-4-phosphate 5-kinase alpha; phosphatidylinositol-4-phosphate 5-kinase type 1 alpha; PIP5KIalpha (PIP5K1A)

Function

• biosynthesis of phosphatidylinositol-4,5-bisphosphate
• mediates RAC1-dependent reorganization of actin filaments
• activation of PLD2
• interacts with ARF1, RAC1, PLD1, PLD2 & JUB

Structure

contains 1 PIPK domain

Compartment

• cell membrane, endomembrane system. Golgi, Golgi stack (putative)
• nuclear speckle
• associated with the plasma membrane & with internal membranes
• associated with Golgi stacks (putative)
• detected on RAC1-induced plasma membrane ruffles, & on membrane ruffles
• induced by platelet-derived growth factor
• localizes to nuclear speckles & associates with TUT1 to regulate polyadenylation of selected mRNAs

Alternative splicing

named isoforms=4

Expression

• expressed in heart, placenta, skeletal muscle, kidney, pancreas > brain, lung, liver

More general terms

• phosphoinositide-5-kinase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8394
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8394
• OMIM: https://mirror.omim.org/entry/603275
• UniProt: http://www.uniprot.org/uniprot/Q99755.html