phospholipase-D2, choline phosphatase 2 (phosphatidylcholine-hydrolyzing phospholipase D2, hPLD2, PLD1C, PLD2)

Function

• phospholipase-D hydrolyzes (PLD) phosphatidylcholine to phosphatadic acid + choline
• PLD may be activated by ceramide
• may have a role in signal-induced cytoskeletal regulation &/or endocytosis (putative)
• interacts with EGFR (putative)
• interacts with PIP5K1A
• stimulated by phosphatidylinositol 4,5-bisphosphate & activated by the ADP-ribosylation factor-1 (ARF-1)

phosphatidylcholine + H2O <--> choline + a phosphatidate

Structure

• belongs to the phospholipase D family
• contains 1 PH domain
• contains 2 PLD phosphodiesterase domains
• contains 1 PX (phox homology) domain

Compartment

peripheral membrane

Alternative splicing

named isoforms=3

Expression

ubiquitous

More general terms

• phospholipase-D (PLD)

Additional terms

• ceramide

Database

• OMIM: https://mirror.omim.org/entry/602384
• UniProt: http://www.uniprot.org/uniprot/O14939.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5338