phox homology [PX] domain

Introduction

100-140 amino acid domain that function as phosphoinositide- binding domain. Many PX domains contain a proline-rich region representing an SH3-binding site. Thus SH3 docking might regulate interaction between PX domains & phosphoinositide-enriched membranes. The PX domain also contains several conserved positively charged & hydrophobic residues that may bind phosphoproteins or phospholipids.

More general terms

• domain
• peptide motif

Additional terms

• cytochrome b558 alpha subunit (p22 phagocyte B-cytochrome, neutrophil cytochrome B, 22 kD polypeptide, p21/p22phox, superoxide-generating NADPH oxidase light chain subunit, CYBA)
• neutrophil cytosol factor 4 (NCF-4, neutrophil NADPH oxidase factor 4, p40-phox, p40phox, NCF4)
• p47phox (neutrophil cytosol factor-1, NCF-1, NCF-47K, 47 kD autosomal chronic granulomatous disease protein, Nox-organizing protein 2, SH3 & PX domain-containing protein 1A, NCF1, NOXO2, SH3PXD1A)
• p67phox; neutrophil cytosol factor-2; NCF-2; neutrophil NADPH oxidase factor