cytochrome b558 alpha subunit (p22 phagocyte B-cytochrome, neutrophil cytochrome B, 22 kD polypeptide, p21/p22phox, superoxide-generating NADPH oxidase light chain subunit, CYBA)

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Function

Structure

  • belongs to the p22phox family
  • heme prosthetic group could be coordinated with residues of the light chain, the heavy chain, or both

Pathology

More general terms

Additional terms

Component of

References

  1. Rotrosen D, Yeung CL, Leto TL, Malech HL, Kwong CH. Cytochrome b558: the flavin-binding component of the phagocyte NADPH oxidase. Science. 1992 Jun 5;256(5062):1459-62. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1318579
  2. Segal AW, Abo A. The biochemical basis of the NADPH oxidase of phagocytes. Trends Biochem Sci. 1993 Feb;18(2):43-7. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/8488557
  3. Pawson T Protein modules and signalling networks Nature 373:573 1995 PMID: https://www.ncbi.nlm.nih.gov/pubmed/7531822
  4. CYBAbase; CYBA mutation db http://bioinf.uta.fi/CYBAbase/
  5. GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=CYBA
  6. SHMPD; The Singapore human mutation & polymorphism database http://shmpd.bii.a-star.edu.sg/gene.php?genestart=C&genename=CYBB+%40+GP91-PHOX
  7. UniProt http://www.uniprot.org/uniprot/P13498.html

Database