dual oxidase 1; large NOX 1; long NOX 1; NADPH thyroid oxidase 1; thyroid oxidase 1 (DUOX1, DUOX, LNOX1, THOX1)

Function

• generates hydrogen peroxide required for activity of thyroid peroxidase lactoperoxidase
• thyroid hormones synthesis
• lactoperoxidase-mediated antimicrobial defense at the surface of mucosa
• may have intrinsic peroxidase activity through N-terminal peroxidase-like domain
• NADPH oxidase activity is Ca+2-dependent.
• interacts with TXNDC11, TPO, CYBA

Structure

• N-glycosylated
• in the N-terminal section; belongs to the peroxidase famiily
• contains 3 EF-hand domains
• contains 1 FAD-binding FR-type domain
• contains 1 ferric oxidoreductase domain

Compartment

• localizes to the apical membrane of epithelial cells

Alternative splicing

named isoforms=2

Expression

• expressed in thyrocytes, tracheal surface epithelial cells, thyroid, trachea, bronchium > placenta, testis, prostate, pancreas, heart
• widely expressed in fetal tissues
• induction by forskolin, thyrotropin, IL-4, IL-13

More general terms

• oxidoreductase
• transmembrane 7 protein
• Ca+2 binding protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=53905
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:53905
• OMIM: https://mirror.omim.org/entry/606758
• UniProt: http://www.uniprot.org/uniprot/Q9NRD9.html