thyroid-stimulating hormone (TSH) or thyrotropin

Function

• stimulates thyroxine secretion by the thyroid

Compartment

secreted

Expression

secreted by the anterior pituitary

Pathology

• anti-thyrotropin Ab in Graves disease
• deficiency associated with secondary hypothyroidism
• overproduction associated with secondary hyperthyroidism (rare) & (more commonly) a physiologic response to primary hypothyroidism

Biochemistry

• carbohydrate sulfotransferase (CHST8, CHST9) required for biosynthesis of thyrotropin

Laboratory

• thyrotropin in blood
  • thyrotropin in blood spot
• thyroid-stimulating hormone in saliva
• thyroid-stimulating hormone in serum
• thyrotropin Ag in tissue
• thyrotropin Ab in serum

More general terms

• anterior pituitary hormone
• multisubunit protein
• glycoprotein

Additional terms

• pituitary adenoma/TSH secreting
• thyroid-stimulating hormone (TSH) in serum; thyrotropin in serum
• thyrotropin receptor; thyroid-stimulating hormone receptor; TSH-R (TSHR LGR3)
• thyrotropin-releasing hormone; thyroliberin; protirelin (TRH)
• thyroxine (T4)
• triiodothyronine (T3, liothyronine, Cytomel)

Database

• OMIM: https://mirror.omim.org/entry/145650
• OMIM: https://mirror.omim.org/entry/188530
• OMIM: https://mirror.omim.org/entry/275100