carbohydrate sulfotransferase 9; galNAc-4-O-sulfotransferase 2; galNAc-4-ST2; galNAc4ST-2; N-acetylgalactosamine-4-O-sulfotransferase 2 (CHST9)

Function

• catalyzes transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (galNAc) residues in both N-glycans & O-glycans
• role in biosynthesis of glycoprotein hormones lutropin & thyrotropin, by mediating sulfation of their carbohydrate structures
• higher activity toward carbonic anhydrase VI than toward lutropin
• only active against terminal galNAcbeta1,galNAcbeta
• isoform 2, but not isoform 1, is active toward chondroitin

Structure

belongs to the sulfotransferase 2 family

Compartment

• isoform 1:
  • Golgi membrane
  • single-pass type 2 membrane protein (putative)
• isoform 2: secreted (probable)

Alternative splicing

named isoforms=2

Expression

• highly expressed in trachea
• also expressed in fetal lung, adult pancreas, testis & salivary gland
• expressed at low level in pituitary gland, apex of the heart, adult lung, prostate & mammary gland
• weakly or not expressed in heart, liver & spinal cord

Notes

• uncertain whether Met-1 or Met-8 is the initiator

More general terms

• carbohydrate sulfotransferase (CHST)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=83539
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:83539
• OMIM: https://mirror.omim.org/entry/610191
• UniProt: http://www.uniprot.org/uniprot/Q7L1S5.html